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Semaglutide

CAS No.: 910463-68-2

Formula: C187H291N45O59

Molecular Weight: 4113.57754

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What is Semaglutide

**Introduction to Semaglutide** Semaglutide is an innovative medication used to manage type 2 diabetes and, more recently, chronic weight management in adults. As a glucagon-like peptide-1 (GLP-1) receptor agonist, it mimics natural hormones to regulate blood sugar levels by stimulating insulin secretion, suppressing glucagon release, and slowing gastric emptying. Clinically proven to improve glycemic control and support weight loss, semaglutide is available in both injectable (Ozempic®, Wegovy®) and oral (Rybelsus®) forms. Its dual benefits make it a valuable option for patients struggling with obesity-related metabolic conditions. With strong efficacy and a favorable safety profile, semaglutide represents a significant advancement in diabetes and weight management therapies.

Preparation Process: Semaglutide is prepared via solid-phase peptide synthesis (SPPS) using Fmoc chemistry. The sequence H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(Boc)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg(Trt)-Gly-Arg(Trt)-Gly-OH is assembled on a Rink amide resin. Aib (α-aminoisobutyric acid) at position 2 enhances stability. After chain assembly, the peptide is cleaved from the resin using TFA/water/TIS (95:2.5:2.5). The crude peptide is purified via reverse-phase HPLC. A C18 fatty diacid (octadecanedioic acid) is then conjugated to the Lys side chain via a γ-Glu spacer using DIC/HOBt coupling. Final purification by HPLC yields Semaglutide as a white lyophilized powder.

Usage Scenarios: Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist primarily used to manage type 2 diabetes by improving blood sugar control. It stimulates insulin secretion, suppresses glucagon release, and slows gastric emptying, reducing postprandial glucose spikes. Additionally, semaglutide is approved for chronic weight management in adults with obesity or overweight conditions, as it promotes satiety and reduces appetite. Administered via subcutaneous injection, it is available in varying dosages under brand names like Ozempic (for diabetes) and Wegovy (for weight loss). Studies also suggest potential cardiovascular benefits in reducing major adverse cardiac events in high-risk patients.

Semaglutide Basic Info

Chemical Name Semaglutide

Synonyms semaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;Sermaglutide CAS 910463 68 2;OG217SC;Ozempic;Somaroutin;semgalutide;Somaglutide;Somarlutide

CAS No. 910463-68-2

Molecular Formula C187H291N45O59

Molecular Weight 4113.57754

PSA 1646.18000

LogP 5.44520

Safely Info

RTECS -

Hazard Class -

Safety Statements -

HS Code -

WGK Germany -

Packing Group -

RIDADR -

Risk Statements -

Hazard Codes -

Caution Statement P201-P202-P281-P308+P313-P405-P501

Hazard Declaration H361

Symbol GHS08

Signal Word Warning

Semaglutide Price

Here is a rough price range for Semaglutide (a medication used for diabetes and weight management) in the listed countries. Note that prices can vary based on dosage, brand, and local regulations. If no specific data is available, it is marked as "No results":

1. **United States**: $800–$1,500 per month
2. **China**: $300–$600 per month
3. **Russia**: $400–$800 per month
4. **Germany**: $200–$500 per month
5. **India**: $100–$300 per month
6. **Japan**: $500–$1,000 per month
7. **Brazil**: $300–$700 per month
8. **South Korea**: $400–$800 per month
9. **Philippines**: No results
10. **United Kingdom**: $200–$500 per month
11. **France**: $200–$500 per month
12. **Mexico**: $300–$700 per month
13. **Canada**: $500–$1,000 per month
14. **South Africa**: $300–$600 per month
15. **Egypt**: No results
16. **Turkey**: $200–$500 per month
17. **Thailand**: $200–$500 per month
18. **Indonesia**: No results

These ranges are approximate and may vary based on local market conditions, insurance coverage, and availability.