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Hydroxypropyl cellulose

CAS No.: 9004-64-2
Formula: C3H7O*
Molecular Weight: 59.08708
Suppliers: All(0) China Suppliers(9) Products(22)
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What is Hydroxypropyl cellulose

**Introduction to Hydroxypropyl Cellulose (HPC)** Hydroxypropyl Cellulose (HPC) is a non-ionic, water-soluble cellulose ether derived from natural cellulose through chemical modification. It exhibits excellent film-forming, thickening, binding, and stabilizing properties, making it widely used in pharmaceuticals, cosmetics, food, and industrial applications. HPC is biocompatible, biodegradable, and thermally reversible, forming gels upon heating. In pharmaceuticals, it serves as a tablet binder, coating agent, and sustained-release matrix. In cosmetics, it enhances texture and stability in creams and shampoos. Its solubility in both cold water and organic solvents offers versatility in formulations. With low toxicity and high compatibility, HPC is a preferred excipient in diverse industries.

Preparation Process: Hydroxypropyl cellulose (HPC) is prepared by reacting cellulose with propylene oxide in an alkaline medium. First, cellulose is activated by soaking in sodium hydroxide solution to form alkali cellulose. The alkali cellulose is then treated with propylene oxide under controlled temperature (typically 20–60°C) and pressure to introduce hydroxypropyl groups via etherification. The reaction mixture is neutralized with acid, and the product is purified by washing with water or organic solvents to remove unreacted reagents and byproducts. The resulting HPC is dried and milled into a fine powder. The degree of substitution (DS) can be adjusted by varying reaction conditions.

Usage Scenarios: Hydroxypropyl cellulose (HPC) is a water-soluble polymer derived from cellulose, widely used in pharmaceuticals, cosmetics, and food industries. In pharmaceuticals, it acts as a binder, film-coating agent, and controlled-release matrix in tablets. It enhances viscosity and stabilizes emulsions in topical gels, ointments, and ophthalmic solutions. In cosmetics, HPC functions as a thickener, emulsifier, and film-forming agent in shampoos, creams, and mascaras. The food industry employs it as a stabilizer, thickener, and emulsifier in products like sauces and dairy items. Its biocompatibility, non-toxicity, and solubility in cold water make it versatile for various applications. HPC also aids in 3D printing as a support material.

Hydroxypropyl cellulose Basic Info
Chemical Name Hydroxypropyl cellulose
Synonyms HPC;hydroxypropyl;L-HPC;KLUCEL;Hyprolose;Low-Substituted Hydroxypropyl cellulose;Hydroxypropyl cellulose - Average MW 80,000;Hydroxypropyl cellulose - Average MW 370,000;Hydroxypropyl cellulose - Average MW 1,000,000;Hydroxypropyl cellulose - Average MW 50,000 - 1250,000
CAS No. 9004-64-2
Molecular Formula C3H7O*
Molecular Weight 59.08708
PSA 0.00000
LogP 0.00000
Safely Info
RTECS NF9050000
Hazard Class -
Safety Statements 24/25
HS Code 39129000
WGK Germany -
Packing Group -
RIDADR -
Risk Statements -
Hazard Codes -
Caution Statement P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Declaration H302-H335-H332-H319-H315
Symbol GHS07
Signal Word Warning
Hydroxypropyl cellulose Price
United States: $100 - $150
China: $75 - $100
Russia: $80 - $120
Germany: $120 - $160
India: $50 - $80
Japan: $100 - $150
Brazil: $90 - $120
South Korea: $80 - $110
Philippines: $70 - $100
United Kingdom: $110 - $150
France: $100 - $140
Mexico: $70 - $100
Canada: $100 - $140
South Africa: $60 - $90
Egypt: $50 - $80
Turkey: $80 - $120
Thailand: $70 - $100
Indonesia: No results
MSDS
MSDS
Name: Hydroxypropyl Cellulose Average Mol. Weight 100.000 Material Safety Data Sheet
Synonym: Oxypropylated Cellulos
CAS: 9004-64-2
Section 1 - Chemical Product   MSDS Name:Hydroxypropyl Cellulose Average Mol. Weight 100.000 Material Safety Data Sheet
Synonym:Oxypropylated Cellulos

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
9004-64-2 Hydroxypropyl Cellulose ca 100 unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin:
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 9004-64-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: Not available.
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: 400 deg C ( 752.00 deg F)
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: many polar organic solvents
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 9004-64-2: NF9050000 LD50/LC50:
CAS# 9004-64-2: Oral, mouse: LD50 = >5 gm/kg; Oral, rat: LD50 = 10200 mg/kg.
Carcinogenicity:
Hydroxypropyl Cellulose - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 9004-64-2: No information available.
Canada
CAS# 9004-64-2 is listed on Canada's DSL List.
CAS# 9004-64-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 9004-64-2 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
SDS 1.0
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