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Insulin degludec

CAS No.: 844439-96-9

Formula: C274H411N65O81S6

Molecular Weight: 6103.97204

Suppliers: All(0) China Suppliers(1) Products(1)

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What is Insulin degludec

**Introduction to Insulin Degludec** Insulin degludec is a long-acting basal insulin analog designed to provide stable and prolonged blood glucose control in individuals with diabetes. With an ultra-long duration of action exceeding 42 hours, it offers consistent insulin coverage with once-daily dosing, reducing the risk of hypoglycemia, particularly nocturnal episodes. Its unique mechanism involves the formation of multi-hexamers at the injection site, ensuring a slow, steady release into the bloodstream. Clinically proven for both type 1 and type 2 diabetes, insulin degludec provides flexible dosing times, making it a convenient option for patients with varying schedules. Its efficacy and safety profile make it a valuable therapeutic choice for optimized glycemic management.

Preparation Process: Insulin degludec is prepared by recombinant DNA technology using a modified *Saccharomyces cerevisiae* strain. The gene encoding the B29-lysine-desB30 human insulin precursor is expressed and purified. The precursor undergoes enzymatic cleavage to remove the B30 threonine residue, followed by acylation with hexadecanedioic acid via a γ-L-glutamyl spacer at the B29 lysine. The resulting insulin degludec forms multihexamers upon subcutaneous injection, ensuring prolonged action. Purification involves chromatography (e.g., reverse-phase and ion-exchange) and crystallization. The final product is formulated with phenol and zinc for stability. Strict quality control ensures purity, potency, and sterility.

Usage Scenarios: Insulin degludec is a long-acting basal insulin analog used to manage blood glucose levels in adults and children with type 1 or type 2 diabetes mellitus. It provides a stable and prolonged glycemic control with a duration of action exceeding 42 hours, allowing for flexible dosing schedules. Its ultra-long action profile results from slow absorption and multi-hexamer formation at the injection site, ensuring a flat and predictable glucose-lowering effect with a lower risk of hypoglycemia compared to other basal insulins. Administered subcutaneously, it is often prescribed once daily, though timing can vary. It may be combined with rapid-acting insulins or oral antidiabetic agents for optimal glycemic management.

Insulin degludec Basic Info

Chemical Name Insulin degludec

Synonyms Insulin degludec;degludec insulin;Insulin degludec USP/EP/BP;Research Grade Insulin Degludec;Insulin Degludec/ Degludec Insulin

CAS No. 844439-96-9

Molecular Formula C274H411N65O81S6

Molecular Weight 6103.97204

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Insulin degludec Price

Here is a rough price range for the chemical product "Insulin degludec" in the 18 countries listed. Note that prices can vary based on factors like brand, dosage, and healthcare systems. If no specific data is available, it is marked as "No results":

1. **United States**: $300–$600 per vial
2. **China**: $50–$150 per vial
3. **Russia**: $100–$200 per vial
4. **Germany**: $100–$250 per vial
5. **India**: $20–$80 per vial
6. **Japan**: $150–$300 per vial
7. **Brazil**: $50–$150 per vial
8. **South Korea**: $100–$250 per vial
9. **Philippines**: $50–$150 per vial
10. **United Kingdom**: $50–$150 per vial (NHS subsidized)
11. **France**: $50–$150 per vial (subsidized)
12. **Mexico**: $50–$150 per vial
13. **Canada**: $100–$250 per vial
14. **South Africa**: $50–$150 per vial
15. **Egypt**: $30–$100 per vial
16. **Turkey**: $50–$150 per vial
17. **Thailand**: $50–$150 per vial
18. **Indonesia**: $50–$150 per vial

If no specific data is available for a country, it is marked as "No results." Prices are approximate and may vary.