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<(18)O>isopropyl alcohol

CAS No.: 73569-91-2

Formula: C3H8O

Molecular Weight: 62.09480

Suppliers: All(0) China Suppliers(0) Products(0)

Description
Basic Info
Price

What is <(18)O>isopropyl alcohol

**Introduction to (18)O-Isopropyl Alcohol** (18)O-Isopropyl alcohol is a stable isotope-labeled compound where the oxygen atom in isopropanol is replaced with the heavy oxygen isotope (18)O. This high-purity reagent is widely used as a tracer in metabolic studies, reaction mechanisms, and isotopic labeling experiments in chemistry, biochemistry, and pharmaceutical research. Its unique isotopic signature allows for precise tracking in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Additionally, (18)O-isopropyl alcohol serves as a valuable intermediate in synthesizing other (18)O-labeled compounds. With applications in drug development, environmental analysis, and biomedical research, it provides researchers with critical insights into molecular pathways and reaction dynamics. (Word count: ~100)

Preparation Process: To prepare <(18)O>isopropyl alcohol, begin with acetone and <(18)O>-labeled water. Dissolve acetone in anhydrous diethyl ether and cool the mixture to 0°C. Slowly add a Grignard reagent (e.g., methylmagnesium bromide) dropwise under nitrogen, stirring vigorously. After completion, quench the reaction with <(18)O>-labeled water, hydrolyzing the intermediate to form <(18)O>isopropyl alcohol. Extract the product with ether, dry over anhydrous magnesium sulfate, and purify by fractional distillation. Alternatively, reduce <(18)O>-labeled acetone using lithium aluminum hydride (LiAlH4) in dry ether, followed by careful hydrolysis with dilute acid to yield the labeled alcohol. Ensure isotopic purity via analytical techniques.

Usage Scenarios: <(18)O>-labeled isopropyl alcohol is primarily used as a stable isotope tracer in metabolic and pharmacokinetic studies to track the movement and transformation of isopropyl alcohol and its derivatives in biological systems. It aids in elucidating reaction mechanisms, enzyme kinetics, and metabolic pathways, particularly in studies involving alcohol metabolism and oxidative stress. The (18)O label allows precise detection using mass spectrometry or NMR spectroscopy. Additionally, it serves as a reagent in organic synthesis for isotopic labeling of compounds, facilitating research in chemical reaction dynamics, solvent effects, and isotopic exchange studies. Its applications extend to environmental science for tracing pollutant degradation pathways.

<(18)O>isopropyl alcohol Basic Info

Chemical Name <(18)O>isopropyl alcohol

Synonyms propan-2-[18O]ol; <2-(18)O>propan-2-ol; (18)O-incorporated 2-propanol; 2-Propanol-18O

CAS No. 73569-91-2

Molecular Formula C3H8O

Molecular Weight 62.09480

PSA 20.23000

LogP 0.38710

<(18)O>isopropyl alcohol Price

Here is a rough price range for <(18)O>isopropyl alcohol in the listed countries. Note that prices can vary significantly based on supplier, purity, and quantity:

1. **United States**: $500 - $1,500 per gram
2. **China**: $400 - $1,200 per gram
3. **Russia**: No results
4. **Germany**: $600 - $1,600 per gram
5. **India**: $450 - $1,300 per gram
6. **Japan**: $700 - $1,800 per gram
7. **Brazil**: No results
8. **South Korea**: $550 - $1,400 per gram
9. **Philippines**: No results
10. **United Kingdom**: $650 - $1,700 per gram
11. **France**: $600 - $1,600 per gram
12. **Mexico**: No results
13. **Canada**: $500 - $1,500 per gram
14. **South Africa**: No results
15. **Egypt**: No results
16. **Turkey**: No results
17. **Thailand**: No results
18. **Indonesia**: No results

These ranges are approximate and based on general market trends for isotopic-labeled chemicals. Availability and pricing may vary depending on local suppliers and demand.