citric acid methacrylate

What is citric acid methacrylate

Citric acid methacrylate (CAM) is a versatile and innovative chemical compound that combines the functional properties of citric acid with the reactive capabilities of methacrylate. This unique hybrid molecule is widely used in the development of advanced materials, particularly in the fields of polymer chemistry, biomedical engineering, and coatings. CAM serves as a key monomer or crosslinker, enabling the creation of biocompatible, biodegradable, and pH-responsive polymers. Its applications range from drug delivery systems and tissue engineering scaffolds to adhesives and coatings with enhanced mechanical and chemical properties. With its dual functionality and eco-friendly profile, CAM is a valuable building block for sustainable and high-performance material design.

Preparation Process: To prepare **citric acid methacrylate**, dissolve **citric acid (1 mol)** in **dry dimethylformamide (DMF)** under nitrogen. Add **methacrylic anhydride (3 mol)** dropwise at 0°C, followed by **4-dimethylaminopyridine (DMAP, catalytic amount)**. Stir at room temperature for **12–24 hours**. Monitor reaction progress by **TLC** or **HPLC**. Quench with **ice water**, extract with **ethyl acetate**, and wash the organic layer with **brine** and **5% NaHCO₃**. Dry over **anhydrous Na₂SO₄**, filter, and concentrate under **reduced pressure**. Purify by **column chromatography (silica gel, ethyl acetate/hexane)** to obtain the product.

Usage Scenarios: Citric acid methacrylate is a multifunctional monomer used primarily in polymer chemistry and material science. It combines the properties of citric acid and methacrylate, offering reactive sites for crosslinking and polymerization. This compound is utilized in the synthesis of biodegradable and biocompatible polymers, particularly for medical applications such as drug delivery systems, tissue engineering scaffolds, and dental materials. Its carboxyl and vinyl groups enable covalent bonding with other monomers, enhancing mechanical strength and functionality. Additionally, citric acid methacrylate is employed in hydrogels, adhesives, and coatings due to its water solubility, adhesive properties, and ability to form stable networks under UV or thermal curing.

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