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[bmim]ibuprofen

CAS No.: 1289675-16-6

Formula: C21H32N2O2

Molecular Weight: 344.49100

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Description
Basic Info
Price

What is [bmim]ibuprofen

[bmim]ibuprofen is an innovative ionic liquid-based pharmaceutical formulation that combines the anti-inflammatory and analgesic properties of ibuprofen with the unique physicochemical characteristics of the 1-butyl-3-methylimidazolium ([bmim]) cation. This hybrid compound leverages the advantages of ionic liquids, such as enhanced solubility, stability, and bioavailability, to improve the delivery and efficacy of ibuprofen. By integrating the active pharmaceutical ingredient (API) into an ionic liquid structure, [bmim]ibuprofen offers a promising solution to challenges associated with traditional drug formulations, including poor water solubility and limited absorption. This product represents a cutting-edge approach in pharmaceutical science, paving the way for more efficient and patient-friendly drug delivery systems.

Preparation Process: The preparation of [bmim]ibuprofen involves a metathesis reaction. First, 1-butyl-3-methylimidazolium chloride ([bmim]Cl) is dissolved in acetone. Separately, sodium ibuprofen is prepared by neutralizing ibuprofen with sodium hydroxide in water. The sodium ibuprofen solution is then slowly added to the [bmim]Cl solution under stirring at room temperature. The mixture is stirred for 12–24 hours to ensure complete ion exchange. The resulting [bmim]ibuprofen precipitates as a viscous liquid. The product is washed repeatedly with water to remove NaCl and unreacted starting materials, then dried under vacuum to yield pure [bmim]ibuprofen as a colorless to pale yellow ionic liquid.

Usage Scenarios: [bmim]ibuprofen, an ionic liquid combining the 1-butyl-3-methylimidazolium ([bmim]) cation with ibuprofen as the anion, serves as a dual-functional compound with both pharmaceutical and solvent properties. It enhances drug solubility and bioavailability, improving ibuprofen's therapeutic efficacy. Its ionic liquid nature allows for tunable physicochemical properties, making it useful in drug delivery systems. Additionally, [bmim]ibuprofen can act as a green solvent in chemical reactions, reducing the need for volatile organic compounds. Its anti-inflammatory and analgesic effects are retained, while its liquid state at room temperature facilitates novel formulations like transdermal patches or topical gels. This compound also shows potential in controlled-release applications and multi-drug formulations.

[bmim]ibuprofen Basic Info

Chemical Name [bmim]ibuprofen

Synonyms [BMIM][Ibu]; 1-methyl-3-butylimidazolium ibuprofenate; 1-butyl-3-methylimidazolium ibuprofenate; BMImIbu; 1-Butyl-3-methylimidazolium ibuprofenate

CAS No. 1289675-16-6

Molecular Formula C21H32N2O2

Molecular Weight 344.49100

PSA 48.94000

LogP 2.85120

[bmim]ibuprofen Price

Here is a rough price range for [bmim]ibuprofen in each of the 18 countries, based on factors such as economic standards, healthcare policies, and market conditions. Note that these are approximate estimates and may vary depending on specific formulations or purchasing channels.

1. **United States**: $20–$50 per bottle
2. **China**: $5–$20 per bottle
3. **Russia**: $10–$30 per bottle
4. **Germany**: €15–€50 per bottle
5. **India**: $3–$10 per bottle
6. **Japan**: ¥1,500–¥5,000 per bottle ($12–$45)
7. **Brazil**: $10–$30 per bottle
8. **South Korea**: ₩30,000–₩90,000 per bottle ($26–$74)
9. **Philippines**: $2–$10 per bottle
10. **United Kingdom**: £10–£40 per bottle ($13–$52)
11. **France**: €15–€50 per bottle
12. **Mexico**: $8–$25 per bottle
13. **Canada**: C$25–C$75 per bottle ($19–$56)
14. **South Africa**: $10–$30 per bottle
15. **Egypt**: $5–$15 per bottle
16. **Turkey**: $10–$30 per bottle
17. **Thailand**: $5–$15 per bottle
18. **Indonesia**: $2–$6 per bottle

These estimates assume [bmim]ibuprofen is a chemical product or specialized pharmaceutical formulation. Actual prices may vary based on availability and market conditions. For precise pricing, consult local suppliers or industry sources.