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Semaglutide intermediate

CAS No.: 1118767-15-9

Formula: C47H82N4O15

Molecular Weight: 943.17

Suppliers: All(0) China Suppliers(0) Products(0)

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What is Semaglutide intermediate

**Introduction to Semaglutide Intermediate** Semaglutide intermediate is a key bioactive compound used in the pharmaceutical synthesis of Semaglutide, a groundbreaking GLP-1 receptor agonist approved for treating type 2 diabetes and obesity. This high-purity intermediate plays a crucial role in ensuring the efficacy, stability, and scalability of the final peptide drug. Manufactured under strict quality controls, it undergoes advanced chemical processes to meet rigorous regulatory standards. Semaglutide intermediate enables efficient large-scale production, supporting the development of innovative therapies that improve glycemic control and weight management. With its critical role in peptide synthesis, this intermediate represents a vital component in advancing metabolic disorder treatments, offering reliability and consistency for pharmaceutical manufacturers worldwide. (100 words)

Preparation Process: Semaglutide intermediate can be prepared through solid-phase peptide synthesis (SPPS) using Fmoc chemistry. Start by attaching Fmoc-Glu(OtBu)-OH to a Wang resin. Sequentially couple Fmoc-protected amino acids (e.g., Fmoc-Lys(Boc)-OH, Fmoc-Ala-OH, Fmoc-Leu-OH, etc.) using HBTU/HOBt/DIPEA as coupling agents. After each coupling, deprotect with 20% piperidine/DMF. Introduce the Aib-Lys(Palmitoyl-Glu-OtBu) side chain via on-resin acylation. Cleave the peptide from the resin using TFA/TIS/H2O (95:2.5:2.5), then purify by reverse-phase HPLC. The crude product is lyophilized to yield the semaglutide intermediate. Optimize reaction conditions (solvent, temperature, equivalents) to improve yield and purity.

Usage Scenarios: Semaglutide intermediate is a key compound used in the pharmaceutical synthesis of Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. It serves as a crucial building block in the step-by-step chemical and enzymatic processes required to produce the active pharmaceutical ingredient (API). The intermediate undergoes further modifications, such as peptide coupling, purification, and side-chain protection, to form the final Semaglutide molecule. This compound ensures high purity and efficiency in large-scale manufacturing. Semaglutide is primarily used to treat type 2 diabetes and chronic weight management, making its intermediate vital for maintaining consistent drug quality and therapeutic efficacy.

Semaglutide intermediate Basic Info

Chemical Name Semaglutide intermediate

Synonyms Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OSu;Carbaryl Impurity 1;tBuO-Ste-yGlu(OtBu)-;Somalutide side chain;Semaglutide Impurity 17;Semaglutide Impurity 45;tBuO-Ste-E(AEEA-AEEA-OSu)-OtBu;tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu;tBuO-C18-Glu(AEEA-AEEA-OSu)-OtBu;tBuO-C18-γGlu(tBu)-AEEA-AEEA-OSU

CAS No. 1118767-15-9

Molecular Formula C47H82N4O15

Molecular Weight 943.17

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Semaglutide intermediate Price

Here is a rough price range for the chemical product "Semaglutide intermediate" in the 18 countries listed. Note that these are approximate ranges and may vary based on suppliers, market conditions, and other factors:

- **United States**: $500 - $1,500 per kg
- **China**: $300 - $800 per kg
- **Russia**: $400 - $1,000 per kg
- **Germany**: $600 - $1,200 per kg
- **India**: $200 - $600 per kg
- **Japan**: $700 - $1,500 per kg
- **Brazil**: $400 - $900 per kg
- **South Korea**: $500 - $1,000 per kg
- **Philippines**: No results
- **United Kingdom**: $600 - $1,300 per kg
- **France**: $600 - $1,200 per kg
- **Mexico**: $400 - $900 per kg
- **Canada**: $500 - $1,200 per kg
- **South Africa**: $300 - $800 per kg
- **Egypt**: No results
- **Turkey**: $400 - $900 per kg
- **Thailand**: $300 - $700 per kg
- **Indonesia**: $200 - $600 per kg

These ranges are based on general market trends and may not reflect real-time or specific supplier pricing. For accurate pricing, contacting suppliers directly is recommended.