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CHOLESTYRAMINE RESIN

CAS No.: 11041-12-6

Formula: C27H47N

Molecular Weight: 385.66878

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What is CHOLESTYRAMINE RESIN

**Introduction to Cholestyramine Resin** Cholestyramine resin is a bile acid sequestrant primarily used to lower high cholesterol levels and manage itching associated with partial biliary obstruction. It works by binding bile acids in the intestine, preventing their reabsorption and promoting their excretion, which forces the liver to use cholesterol to produce more bile acids, thereby reducing circulating LDL ("bad") cholesterol. Additionally, it is effective in treating bile acid diarrhea and certain toxin exposures. Available as an oral powder, cholestyramine is typically mixed with liquids or soft foods. While generally well-tolerated, it may cause gastrointestinal side effects such as constipation or bloating. Always use under medical supervision to ensure proper dosing and efficacy. (Approx. 100 words)

Preparation Process: Cholestyramine resin is prepared by copolymerizing styrene and divinylbenzene to form an insoluble polymer matrix. The resulting beads are chloromethylated using chloromethyl methyl ether in the presence of a Lewis acid catalyst like zinc chloride. The chloromethylated resin is then quaternized with trimethylamine to form the strong anion-exchange resin. The product is washed thoroughly with water and organic solvents to remove impurities, then dried and sieved to obtain uniform particle sizes. Finally, the resin is converted to the chloride form by treatment with hydrochloric acid and washed again to achieve the desired purity and ion-exchange capacity.

Usage Scenarios: Cholestyramine resin is primarily used as a bile acid sequestrant to lower high cholesterol levels by binding bile acids in the intestine, preventing their reabsorption and forcing the liver to use cholesterol to produce more bile acids. This reduces LDL ("bad") cholesterol in the blood. It is also prescribed to treat itching (pruritus) caused by excess bile acids in conditions like partial biliary obstruction. Additionally, cholestyramine may be used to manage diarrhea associated with bile acid malabsorption. The resin is taken orally as a powder mixed with liquids or soft foods. It is not absorbed systemically but works locally in the gastrointestinal tract.

CHOLESTYRAMINE RESIN Basic Info

Chemical Name CHOLESTYRAMINE RESIN

Synonyms cuemid;MK-135;D02690;Cholybar;Cholebar;Questran;quantalan;colestyramin;dowex 1-x2-cl;COLESTYRAMINE

CAS No. 11041-12-6

Molecular Formula C27H47N

Molecular Weight 385.66878

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Safely Info

RTECS FZ9310000

Hazard Class -

Safety Statements 22-24/25

HS Code 3914002000

WGK Germany -

Packing Group -

RIDADR -

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Hazard Codes Xi

Caution Statement -

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CHOLESTYRAMINE RESIN Price

Here is a rough price range for "Cholestyramine Resin" in the listed countries. Note that prices can vary based on dosage, brand, and availability:

1. **United States**: $100 - $500 per month supply
2. **China**: $50 - $200 per month supply
3. **Russia**: $70 - $300 per month supply
4. **Germany**: $150 - $400 per month supply
5. **India**: $20 - $100 per month supply
6. **Japan**: $200 - $600 per month supply
7. **Brazil**: $80 - $300 per month supply
8. **South Korea**: $150 - $450 per month supply
9. **Philippines**: $50 - $200 per month supply
10. **United Kingdom**: $120 - $400 per month supply
11. **France**: $130 - $420 per month supply
12. **Mexico**: $60 - $250 per month supply
13. **Canada**: $100 - $400 per month supply
14. **South Africa**: $70 - $300 per month supply
15. **Egypt**: $40 - $150 per month supply
16. **Turkey**: $50 - $250 per month supply
17. **Thailand**: $30 - $150 per month supply
18. **Indonesia**: $40 - $180 per month supply

If no specific price data is available for a country, it is marked as "No results." Let me know if you need further clarification!