moxifloxacin tartaric acid

What is moxifloxacin tartaric acid

**Introduction to Moxifloxacin Tartaric Acid** Moxifloxacin tartaric acid is a pharmaceutical compound combining moxifloxacin, a potent fourth-generation fluoroquinolone antibiotic, with tartaric acid to enhance stability and solubility. It is primarily used to treat bacterial infections, including respiratory, skin, and intra-abdominal infections, by inhibiting bacterial DNA gyrase and topoisomerase IV. The addition of tartaric acid improves its formulation properties, ensuring better bioavailability and efficacy. Moxifloxacin tartaric acid is valued for its broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens. Available in oral and intravenous forms, it is a critical therapeutic option for severe infections where resistance to other antibiotics is a concern. Its safety and effectiveness make it a trusted choice in clinical practice.

Preparation Process: To prepare moxifloxacin tartaric acid, dissolve moxifloxacin hydrochloride (1 equivalent) in a mixture of water and ethanol (1:1 v/v) at room temperature. Separately, dissolve L-tartaric acid (1 equivalent) in warm water. Slowly add the tartaric acid solution to the moxifloxacin solution under stirring. Adjust the pH to 3.5–4.0 using dilute NaOH or HCl. Stir the mixture for 2–3 hours at 50–60°C, then cool to room temperature. Filter the precipitated solid, wash with cold ethanol, and dry under vacuum at 50°C for 6–8 hours. Recrystallization from ethanol-water improves purity.

Usage Scenarios: Moxifloxacin tartaric acid is a combination of the broad-spectrum fluoroquinolone antibiotic moxifloxacin and tartaric acid, primarily used to enhance solubility and stability for pharmaceutical formulations. It is indicated for treating bacterial infections, including respiratory tract infections (such as pneumonia, bronchitis, and sinusitis), skin and soft tissue infections, and intra-abdominal infections caused by susceptible Gram-positive, Gram-negative, and atypical pathogens. The tartaric acid component aids in improving bioavailability and absorption. Moxifloxacin tartaric acid is administered orally or intravenously, depending on the severity of the infection. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and leading to bacterial cell death.

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